RELATIONSHIP BETWEEN LDH AND MG IN MONITORING OF HEMATOLOGIC AND NON-HEMATOLOGIC MALIGNANT DISEASES

Description

Aurelian Udristioiu

Aim of this study was to evaluate the correlation between the serum levels of lactate dehydrogenase (LDH) and magnesium (Mg) in patients with diagnosed malignant diseases.
Method: Were analyzed LDH and Mg parameters on a cohort of patients (n = 75) comprising males (n= 36) and females (n=39) with a mean age of 57 years (SD= 12.5).The biochemical parameters were measured using a Vitros 250 dry chemistry analyzer (Johnson & Johnson, USA) using the slides for multi-layer spectrophotometry measurements.
Results; In the cohort study, 55 patients (73%) who received cancer therapy exhibited normal serum levels of Mg (normal value = 1.60-2.3 mg/dL; mean value = 2.2 mg/dL; SD = 0.2; p = 0.02). In contrast, 12 patients (16%), recently diagnosed with a malignant disease, who had not been treated, displayed high levels of serum Mg, (mean value = 2.89 mg/dL). Serum Mg levels were increased by the release of Mg² + from malignant tissues in patients with malignant disease prior to treatment with cytostatic drugs. LDH levels remained elevated after initial cytostatic treatment until cancer remission. The number of copies of chromosomes in malignant tumors may be correlated with total serum LDH values.
Conclusion: Normal Mg levels with moderately elevated LDH levels were observed in all patients with regressive cancer after good responses to specific therapy. Low Mg levels with high serum LDH levels have also been observed in all patients with poor prognosis and metastases, meaning that Mg and LDH ion levels can be used as markers to monitor treatment responses in patients with or without metastasis.

https://doi.org/10.58679/UTM95389