INTEGRATION OF ARTIFICIAL INTELLIGENCE IN DRUG DEVELOPMENT AND MANUFACTURING: EVALUATING THE EFFICACY OF MINOXIDIL AND SILDENAFIL IN ALOPECIA TREATMENT
Iulian SÂRBU, Măriuca-Roxana GAVRILOAIA, Erand MATI, Anton ALDEA, Ion MIRCIOIU, Mirela Claudia RÎMBU In the digital age of the 21st century, Artificial Intelligence (AI) has emerged as a crucial tool across various domains, including the pharmaceutical industry. This paper explores … Read More
DRUG INTERACTION ANALYSIS USING ARTIFICIAL INTELLIGENCE
Măriuca-Roxana GAVRILOAIA, Sorina Nicoleta AURICĂ, Cristina Maria FĂCĂLEȚ, Mariana PANŢUROIU, Luiza CIMA, Luciana GĂLĂȚANU, Anton ALDEA, Iulian SÂRBU, Mirela Claudia RÎMBU Artificial Intelligence (AI) is revolutionizing drug interaction analysis, providing healthcare with powerful tools to enhance patient safety and treatment … Read More
ANALYSIS OF PHYSICOCHEMICAL AND ANTIOXIDANT PROPERTIES OF ARGAN, ALMOND, AND JOJOBA OILS
Luiza-Mădălina CIMA, Mona Luciana GĂLĂȚANU, Alexandra Mihaela MINCU, Măriuca-Roxana GAVRILOAIA, Anton ALDEA, Sorina Nicoleta AURICĂ, Mariana PANŢUROIU This research examines the quality and stability of three types of vegetable oils—Argan, Almond, and Jojoba—through a comprehensive series of physicochemical analyses. The … Read More
BEYOND ANTIBIOTICS: THE POTENTIAL OF FUNGI IN NEW DRUG DISCOVERY IN THE AGE OF ANTIMICROBIAL RESISTANCE
Sorina-Nicoleta AURICĂ, Mariana CONSTANTIN, Roxana-Colette SANDULOVICI, Gabriela-Rodica OPRIȘAN, Mariana POPESCU, Măriuca-Roxana GAVRILOAIA, Carmen-Marinela MIHĂILESCU, Carmen-Elisabeta MANEA, Mona Luciana GĂLĂȚANU, Mariana PANȚUROIU, Viorel ORDEANU, Mirela Claudia RÎMBU Antimicrobial resistance (AMR) represents a major global threat, significantly impacting public health and the … Read More
ARTIFICIAL INTELLIGENCE IN PHARMACY: INNOVATION AND HEALTH IMPACT
Erand MATI, Iulian SÂRBU, Horia Sebastian ILIESCU Artificial Intelligence (AI) is transforming the pharmaceutical industry by reshaping each stage of the drug development process—from drug discovery and molecular design to personalized medicine, clinical trials, and pharmacovigilance. Through sophisticated tools like … Read More
EVALUATION OF ANTIOXIDANT ACTIVITY AND BIOACTIVE COMPOUND CONTENT IN SILYBUM MARIANUM, CYNARA SCOLYMUS, AND TARAXACUM OFFICINALE: SYNERGISTIC POTENTIAL AND THERAPEUTIC IMPLICATIONS
Mariana PANŢUROIU, Mona Luciana GALĂȚANU, Luiza Mădălina CIMA, Roxana Măriuca GAVRILOAIA, Roxana Colette SANDULOVICI, Mariana POPESCU, Daniel CORD, Mirela Claudia RÎMBU This study investigates the flavone and polyphenol content, as well as the antioxidant potential, of a phytopreparation created from … Read More
PHYSICO-CHEMICAL CHARACTERIZATION AND OPTIMIZATION OF COSMETIC PREPARATIONS USING PEPPERMINT OIL
Carmen-Elisabeta MANEA, Carmen-Marinela MIHĂILESCU, Roxana-Collette SANDULOVICI, Mariana POPESCU, Mirela MIHĂILĂ, Gabriela COSTACHE, Marinela CHIRILĂ, Daniel CORD, Viorel ORDEANU, Horia Sebastian ILIESCU, Silvia-Verona ADAM (MĂRGĂRIT This paper examines the characterization and optimization of cosmetic products containing peppermint oil, focusing on its … Read More
COMPARATIVE EVALUATION OF PHARMACEUTICAL FORMULATIONS WITH ENALAPRIL MALEATE. DISSOLUTION TESTING
Ion MIRCIOIU, Roxana-Collete SANDULOVICI, Nora-Denisa RĂDULESCU, Măriuca-Roxana GAVRILOAIA This comparative study investigates the dissolution profiles of four enalapril maleate formulations (Renitec, Enalapril Terapia, Enap KRKA, and Enalapril Slavia), highlighting the impact of excipients on dissolution rate and bioavailability. Enalapril maleate, … Read More
ARE FOOD ADDITIVES (E-NUMBERS) OUR FRIENDS OR ENEMIES?
Viorel ORDEANU, Marinela CHIRILĂ, Gabriela COSTACHE Codex Alimentarius establishes on a scientific basis the Classes and Code Number of approved food additives, just as Pharmacopoeias establish which pharmaceutical substances can be used in therapy. The Lists of food additives are … Read More
ANTIMICROBIAL EFFECT OF SOME ANTI-INFECTIVE CHEMOTHERAPICS COUPLED WITH TRANSITIONAL METALS, AS POSSIBLE INNOVATIVE MEDICINES IN THE ONCOLOGICAL THERAPY
Viorel ORDEANU, Lucia-Elena IONESCU Complex combinations of transition metals represent a distinct class of chemotherapeutic agents, widely used as antitumor and antiviral agents in the clinical practice. The estimated result is to develop, with the possibility of implementation in oncological … Read More
PHASEOLAMIN A HOPE IN THE TREATMENT OF DIABETES AND WEIGHT LOSS CURE
Sabina IONESCU, Radu IONESCU, Horia Sebastian ILIESCU, Camelia PETRESCU The present work presents the action of inactivating pancreatic alpha amylase by the protein called Phaseolamin. Its chemical structure and mode of action in the human body are described, including the … Read More
PSEUDOEPHEDRINE CONTRAINDICATIONS AND APPLICATIONS
Horia Sebastian ILIESCU, Sabina IONESCU, Camelia PETRESCU Pseudoephedrine is an active substance found in plants, with concentrated production in China and India, discovered since 1920. The work presents the mechanism of action, indications, contraindications, and conditions of pseudoephedrine, concluding with … Read More
GEMMOTHERAPY APPROACHES-A REVIEW
Anca-Daniela RAICIU Gemmotherapy is a branch of phytotherapy that focuses on the use of fresh embryonic plant tissues.Gemmotherapy can contribute to the diversification of options for medicinal treatments or natural nutritional supplements, which are increasingly sought after in the context … Read More
VACCINIUM VITIS-IDAEA L. (LINGONBERRY) AND ARCTOSTAPHYLOS UVA-URSI (L). SPRENG. (BEARBERRY): CHEMICAL COMPOSITION, ANTIOXIDANT ACTIVITY
Mariana PANŢUROIU, Mona Luciana GALĂȚANU, Mariana POPESCU, Luiza Mădălina CIMA, Mariana CONSTANTIN, Roxana Colette SANDULOVICI The study aims to evaluate the total content of polyphenols and flavonoids (TPC and TFC) and the antioxidant properties of the methanolic extracts from the … Read More
PHYSICO-CHEMICAL ANALYSIS AND CREAM FORMULATION CONTAINING SILVER NANOPARTICLES FROM ARTHROSPIRAPLATENSIS
Carmen-Marinela MIHĂILESCU, Alexandru GRIGOROIU, Mihaela SAVIN, Veronica ANĂSTĂSOAIE, Oana BRÎNCOVINEANU, Adina BOLDEIU, Roxana-Collette SANDULOVICI, Carmen Aura MOLDOVAN, Carmen Elisabeta MANEA, Mariana CONSTANTIN, Erand MATI, George-Stelian MUSCALU, Marian ION, Silviu DINULESCU, Luciana GĂLĂŢANU, Cristina TĂBLEŢ, Delia Andreea IORDACHE, Adina TURCU This … Read More
CHARACTERIZATION OF PHYSICO-CHEMICAL PARAMETERS FOR SOME COSMETIC PREPARATIONS USING CASTOR AND ARGAN OILS
Carmen-Elisabeta MANEA, Carmen-Marinela MIHĂILESCU, Roxana-Collette SANDULOVICI, Mariana POPESCU, Mirela MIHĂ ILĂ, Gabriela COSTACHE, Marinela CHIRILĂ, Daniel CORD, Viorel ORDEANU, Nicoleta Luciana GEAMĂNU This paper presents the characterization of some physicochemical parameters of two cold pressed vegetable oils, castor oil and … Read More